The form of thermogenesis in humans activated by Buffered Caffeine™ is called Diet-Induced-Thermogenesis (DIT) and is well known in the scientific literature.

Buffered Caffeine™ produces a DIT thermogenic effect, de novo lipogenesis, as well as carbohydrate oxidation (burning) in a Proprietary Low Glycemic matrix.

Adipose tissue (body fat) is a highly active endocrine organ secreting a range of hormones. Energy metabolism and its regulation determine the rate of fat-burning in an individual.

Resisten, Leptin, Ghrelin, Adiponectin, and Lipoprotein Lipase (LPL) play major roles in the function and storage of adipose tissue fat in humans. Leptin (a satiety hormone), adiponectin, and resistin are produced by adipose tissue fat cells. LPL directs food into the fat cells, and is triggered by ingesting high glycemic, fattening foods and/or drinks.

As fat cells increase in size and/or number, Resistin increases, causing increased risk of insulin resistance, obesity, and type 2 diabetes (8). Circulating adiponectin (ACRP30) levels decrease as age progresses, which further increases risk of insulin resistance and type 2 diabetes.

As age increases in humans, adiponectin levels lower, triggering increased abdominal fat deposition, disrupted carbohydrate metabolism, and hyperlipidemia. As a result of these combined factors, decreased thermogenesis is evidenced as humans age and as they gain weight.

In order to combat Stress-Related-Eating (SRE) and False-Food-Cravings, the human body requires the opposite of Glucose-elevation, which is a Low Glycemic Matrix.

A Low Glycemic Matrix does not stimulate glucose, and conversely blocks False-Food-Cravings. The unique Matrix found in Buffered Caffeine™ provides a mechanism for blocking fat-storage and glucose-fat-storage.

The human body, and specifically the brain, requires at least 130 grams of carbohydrates per day for cognitive function and energy. Low energy levels and impaired cognitive function are typical when following a low carb diet.

High glycemic carbohydrates cause glucose and blood sugar swings, fat-storage, and weight gain.

High protein, and low carb diets and foods, exacerbate (worsen) the biochemical stress machine by depriving the body of stress-calming carbohydrates.

Thermogenic drinks and compounds that do not contain a Low Glycemic Matrix cause fat-storage.

Stress, as every woman can attest, causes weight gain.

The link between stress and weight gain has been scientifically proven. At Georgetown University Medical Center, researchers showed that stress conditions cause weight gain, even when caloric intake does not vary.

Stress, experienced as a part of everyday life, triggers the body’s conversion of food energy into glucose as a fight-or-flight hard-wired mechanism. Neuropeptide Y (NPY) is elevated during stress.

NPY attaches to a receptor, a molecular doorway, in fat cells that is called Neuropeptide Y2 receptor, or Y2R. It activates fat cells and some of the cells in blood vessels found in fat tissue.

This cascade of fat-storage mechanisms leads to weight gain as well as depletion of specific B vitamins (particularly B-6), as they are utilized in the Glucose-Producing-Reaction (GPR). As glucose and NPY levels rise, weight gain increases in adipose tissue fat cells.

The human body is hard-wired to gain belly-fat under stress, even mild chronic stress.

STRESS EATING

Stress-Related-Eating (SRE) is caused by biochemical reactions in the body that trigger False-Food-Cravings.

A perfect example of this reaction is PMS, which is generally accompanied by cravings for chocolate, sweets, crunchy foods, and sweet-salty foods (such as chocolate-covered potato chips).

Stress-Related-Eating (SRE) leads to weight gain because the foods craved during SRE elevate glucose production and adipose tissue fat storage. Glucose-elevating foods are High Glycemic. They help sooth stress, but also stimulate fat-storage.